Tuesday, January 12, 2010

Celiac Diease and Yeast

Here is some old research that I just came across: a possible link between Candidiasis (yeast) and Celiac Disease.

The article is a summary and interpretation of a 2003 paper in Lancet by Dr. Nieuwenhuizen.*

The part that gets me interested is [scroll down for the punch line]:

"Now we come to what to me is the most interesting of the recent research regarding celiac. It seems fitting that the research again comes from Holland , where celiac disease was first linked to diet. Dr. Nieuwenhuizen, from the research group TNO Nutrition and Food Research, published a paper in the June, 2003, Lancet. He links celiac disease with Candida albicans. Dr. Nieuwenhuizen, knowing the actual sequence of proteins which trigger celiac disease from the published work of other scientists, had searched the databases available to him through TNO to see if the same sequence existed in other places. It turns out the identical sequence of proteins occur in the cell walls of Candida albicans. [15]

These Candida gluten-like proteins turn out to be the yeast's "hypha-specific surface protein" nicknamed Hwp1. This is the yeast's version of Velcro and allows it to attach and hang onto the endomysium in the wall of the intestine. It is also targeted by transglutaminase, the enzyme which acts on the gluten protein and serves as a target for immune antibodies. Candida species which don't have this Hwp1 protein can't attach themselves to the digestive tract. [16]

If Candida can trigger the same chemical and immunological reactions as wheat gluten do we can imagine a number of interesting implications.
First, in people with celiac disease, symptoms usually get better rapidly when they eliminate gluten from their diet. This isn't always the case. Even without gluten some people continue to have symptoms. They may have intestinal Candidiasis. The Candida in their gut may be acting like gluten and continues triggering symptoms."

*Original article citation:
Is Candida albicans a trigger in the onset of coeliac disease?
The Lancet, Volume 361, Issue 9375, Pages 2152-2154, 21 June 2003


  1. p.s. my acupuncturist recommended Caprylic acid for candida, and I think it actually did help me!

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